2. Purpose . This procedure will administer the compound into the distal esophagus where it will then enter the stomach. Agricultural Research; CCAC guidelines on : the care and use of farm animals in research, teaching and testing; Other resources. Excellence in research is based on outstanding science and adherence to ethical, professional, and regulatory standards associated with the conduct of studies. rat to a temperature around 400C by placing the animal into a thermostatically warmed 'hot-box' (Conybeare et al., 1988), warming the tail under a heating lamp (Waynforth and Flecknell, 1992) or holding the tail in warm water for 1—2 minutes (Fallon, 1996) can induce tail vein dilation. As the guidelines are updated, they will be removed from this Guide and the new guidelines will be posted on the CCAC website under the appropriate heading. Goals for successful euthanasia include techniques requiring minimal restraint, simplicity Pail. Guidelines for the Survival Bleeding of Mice and Rats. RESPONSIBILITY Principal investigator (PI) and their research staff, animal care staff and veterinary care staff. Agricultural Research; CCAC guidelines on : the care and use of farm animals in research, teaching and testing; Other resources. Rats were sacrificed on the 7th and 14th days for pathological examination of the wound. e����7+���ob��/~"p��/���b���9��_A3)Q���K����:{L7\'V6���Y�f.pH'b�.S��Iɻw�(�f��=@+]��j�1cm����z�p@��.wZ�S��|{�]��W��i�>ѣp���f���K� jo�;���S |�����Y\*hdE�wQ��$0��D5�կ�=����A8�E����29�r�4 The cotton rat and the kangaroo rat are both indigenous to North America and belong to the Cricetidae, a separate family from that of the black and Norway rats, which are rodents belonging to the Muridae family. It is recommended to keep gestating and lactating rat dams, and pups up to 3‐4 weeks old, at the higher end of the recommended temperature range (24‐26C), as they have reduced thermoregulatory ability. CCAC resources. The black rat is occasionally found in laboratory colonies, although rarely used in either biomedical or behavioral research. (2011) National Research Council, USA who is responsible at the local level for ensuring that the CCAC guidelines and policies are followed? This is a user guide for the Ratnoze portable sampling system. h�bbd```b`��"�A$� �d1��� ��L~�l�΀��� �,�� // ]]>, Certificate of GAP – Good Animal Practice, National and International Three Rs Centres, Three Rs of Humane Animal Experimentation, Laboratory Animals Used in Biomedical Research, CCAC Certificate of GAP – Good Animal Practice. The CCAC guidelines: Rats (CCAC, 2020) note that exposing rats to carbon dioxide for euthanasia is likely to cause pain and distress (Leach et al., 2004; Moody et al., 2014). : ��in3���NH���nxˡn��՚��.�~ �BZ�8% s��.�nS� ���!�E����*�����ߢ�Yx�QE�|�R|��)����H��>w\���{I���t�z>Ҭ��ԟB3�iCfP�W���[��$�,|�Щ��N����_��9������6:� �Y��c�~հp0���O�:a���w��ӠM,��Y^-I��oɿYU�+'w���#9�3�#yd߮w�����x�>��5}��������/�{ The CCAC guidelines: Rats, states that the basic needs include group housing, shelters, and sufficient space to accommodate these elements and the expression of behaviors important to rat welfare. American Association of Swine Veterinarians (AASV) and National Pork Board (2008) On-Farm Euthanasia of Swine: Recommendations for the Producer.Des Moines IA: National Pork Board. Broom. General Guidelines. CCAC Guidelines: The current CCAC guidelines indicate that for cancer research the experiment must be designed with endpoints that minimize the potential for pain and/or distress. document.write('' + emailE + '<\/a>') endstream endobj startxref Which one if the following approaches is in use in Canada by participants in the CCAC Program? Subcutaneous (SC or SQ) Injection in Rats and Mice SOP Purpose This Standard Operating Procedure (SOP) describes the procedure of subcutaneous injections into rats and mice. ILAR Journal Vol 31, Issue 4, p. 5-20; Rat - Blood draw video (saphenous vein, cardiac puncture) Alberta Government, Agriculture and Rural Development (2007) Firm Steps: Identifying Lameness in Dairy Cattle.Edmonton AB: Alberta Agriculture and Food. 4146 0 obj <>/Filter/FlateDecode/ID[<90C47C91D84E48C49C31241C391AB876><55AB78EB64346C4BA606F51FF4F157B1>]/Index[4128 38]/Info 4127 0 R/Length 102/Prev 1528554/Root 4129 0 R/Size 4166/Type/XRef/W[1 3 1]>>stream Physiological normal values (Depends on age, strain, health status, type of anesthesia, etc.) Fax: 613-238-2837 o@P`�YzLs�ƊN0D���Up�8���"�?5�C�C�y��P��"��"�9���(�Ph9�� ��w,� {�Ҽ_� *�\�;q��lH��� 4165 0 obj <>stream This guidelines document, along with its associated frequently asked questions , addresses conditions normally present in laboratories housing rats, and provides a framework for the implementation of evidence-based practices, with the aim of improving the welfare of rats. ... An investigator has developed a thorough analgesic protocol for experimental surgery on rats. Responsibility Ninety percent of these are rats, mice, fish, and fowl. 1989. Policy: Laurentian University and CCAC guidelines and Regulations. Y�)�f'�b T΍k ,��-��t�{8����\'L�V)�H)U=��l��}ߵ�8��Ǵ�v��s����w~�\� Zb zX�� ��g\H� @#DBZ�� h�D���] �9h� ^���9[CY?�|�b\�*AR��I�9x*! When using oil or viscous gel adjuvant (e.g., FCA) in rabbits, mice or rats, SC is the recommended route. 0 �'� Responsibility: Technologists . DZn��*U@��g �eb�xɟ+_2012l ���Hs�?ç�� *CU Approach-avoidance testing Approach-avoidance testing allows researchers to compare rats’ motivation for a reward against their motivation to avoid gas exposure. the CCAC program are discussed in more detail in following sections. Draw up, into the syringe and needle, the amount of solution to be administered. The CCAC conducts assessment visits to each participating institution using animals. This SOP follows the CCAC guidelines for acceptable injection volumes in rodents. // �&^�6��3�y�;�Č51����^�����o��*��_ʱgˆ�Ǜg�ү�Uda�C��4:՚�x"����u*0��[� �USQ��}Y�����B�� �J�0?��Uc�����U�h廬}�Gx���e'&2������«�.���Xjrq�k �L 8%)�' (1998) Canadian Council on Animal Care, Canada; Guide for the care and use of laboratory animals. The guidelines are based on expert peer advice and current interpretation of … CCAC guidelines are intended to provide assistance in the implementation of Russell and Burch’s Three Rs (Replacement, Reduction and Refinement) principles for animals in science (Russell and Burch, 1959).

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