Learn how surgeons and oncologists at the Medical College of Wisconsin have developed a unique personalized medicine clinical trial for pancreatic cancer. The purpose of this study is to test the safety, tolerability and possible benefit of a drug called tofacitinib in patients with metastatic pancreas cancer when given combined with a standard chemotherapy drug called gemcitabine. open to eligible people ages 18 years and up . Clinical trials are research studies that investigate new treatments or new combinations of treatments. The purpose of this study is to evaluate TST001, a recombinant humanized anti-Claudin 18.2 (CLDN18.2) IgG1 monoclonal antibody, to treat advanced and/or metastatic solid tumors including gastric, gastroesophageal junction, pancreatic, colon and lung cancers. This supports the concept of using FAK inhibitors to reduce stromal fibrosis during checkpoint immunotherapeutic treatment. Some block the ability of tumor cells to grow and spread. Cystic tumors of the pancreas are fluid-filled growths. THe purpose of this study is to examine the current and (potential) future therapeutic relevance of pharmacogenomics (PGx) testing for a cohort of cancer patients in order to improve quality of life (QOL) in patients receiving clinical care at Mayo Clinic. The purpose of this study is to determine the feasibility of performing HIVM in patients with deep space solid tumors during standard course of surgical resection. The purpose of this study is to determine whether oral rucaparib is effective in the treatment of patients with locally advanced or metastatic pancreatic cancer and a known deleterious BRCA mutation. They are often treated by surgical removal. This phase 1 first-in-human study evaluates safety and tolerability of SBP-101 in subjects with previously treated pancreatic ductal adenocarcinoma and will identify the maximum tolerated dose (MTD). Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. The study treats all subjects with nab-Paclitaxel plus gemcitabine for approximately 6 months of treatment. This partially randomized phase I trial studies the side effects and best dose of disulfiram when given together with gemcitabine hydrochloride in treating patients with a solid tumor that cannot be removed by surgery (unresectable) or pancreatic cancer that has spread to other places in the body (metastatic) and to compare whether disulfiram and gemcitabine hydrochloride may reduce tumor induced muscle loss. The Pancreatic Cancer Action Network (PanCAN) strongly recommends clinical trials at diagnosis and during every treatment decision. This is a pilot study to assess safety and efficacy. Through this program and other cutting edge pancreatic cancer research, MD Anderson has: Initiated the first pancreatic cancer high-risk clinic, where family members and those at higher risk for pancreatic cancer (such as adults with new onset diabetes) can be screened and advised. The purpose of this study is to characterize the safety and tolerability of combined treatment with mogamulizumab and nivolumab, and also determine the maximum tolerated dose and the recommended fixed dose for the treatment of patients who have locally advanced or metastatic solid tumors. Individuals who are affected with pancreas cancer and melanoma, as well as those without either cancer who have been identified as 1st or 2nd degree relatives of family members with pancreas cancer and melanoma, will be asked to participate. The study is currently in phase III. Pancreatic cancer clinical trials are necessary to determine whether new treatments developed in the laboratory are beneficial to people living with pancreatic cancer. A Multi-center Trial to Evaluate Multiple Regimens in Metastatic Pancreatic Cancer. Drugs used in chemotherapy, such as fluorouracil, irinotecan hydrochloride, oxaliplatin, gemcitabine hydrochloride, and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Investigators hypothesize that providing dignity therapy to this population will be feasible. A listing of Pancreatic Cancer medical research trials actively recruiting patient volunteers. This is a Phase I, open label study to evaluate the safety, tolerability, and immunogenicity of INO-1400 alone or in combination with INO-9012, delivered by electroporation in subjects with high-risk solid tumor cancer with no evidence of disease after surgery and standard therapy. To determine whether a surveillance program consisting of in a cohort of high-risk individuals results in an excess number of detected and surgically resected high-grade premalignant lesions and early stage pancreatic cancers compared to the natural disease development and manifestation. Ethanol (alcohol) injection may treat cysts by killing the lining cells of the cyst, and is an accepted treatment for cysts of other organs. All rights reserved. Bevacizumab may also stop the growth of cancer by blocking blood flow to the tumor. Evaluate the comparative performance of blood and FDG PET-MRI/MRCP based biomarkers for assessment of response to neoadjuvant therapy in borderline resectable PDAC. Lymphadenopathy (defined as nodes measuring >1 cm in short axis) outside the surgical basin (i.e., para-aortic, peri-caval, celiac axis, or distant nodes) is considered M1 (unless nodes are biopsied and ... To determine whether the microbiome, metagenome and metabolome of the tissue of the second portion of duodenum of patients with pancreatic cancer are different from that of patients with benign conditions not affecting the pancreas. Pancreatic Cancer Clinical Trials for Newest Therapies As part of the Case Comprehensive Cancer Center, UH Seidman Cancer Center is a leading cancer research center and offers many clinical trials for patients with pancreatic cancer. The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer subjects and to develop models for distinguishing cancer from non-cancer. The purpose of this study is to evaluate the side effects and how well the combination of binimetinib and encorafenib work in treating patients with pancreatic cancer with a somatic BRAF V600E mutation. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The Pancreatic Cancer Action Network strongly recommends clinical trials at diagnosis and during every treatment decision. Showing trials for . DISEASE STATE - Potentially operable or borderline resectable pancreatic adenocarcinoma as assessed by standard CT criteria and histologically confirmed. A Study to Collect Survival Data on Patients Previously Enrolled in Abraxane Pancreatic Cancer Study CA046. This randomized phase II trial studies how well standard systemic chemotherapy followed by intensified radiochemotherapy or standard radiochemotherapy preceded by intensified systemic chemotherapy works compared to standard systemic chemotherapy followed by standard radiochemotherapy in treating patients with pancreatic cancer that cannot be removed by surgery. Why Some People in Families Develop Melanoma or Pancreas Cancer, While Still Others Never Develop Cancer, Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers, A Study of AbGn-107 in Patients With Gastric, Colorectal, or Pancreatic Cancer, Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer, A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens, Safety Study of Nivolumab With Nab-Paclitaxel Plus or Minus Gemcitabine in Pancreatic Cancer, Nab-Paclitaxel / Carboplatin in Stage IIIB/IV Non-Small Cell Lung Cancer or Nab-Paclitaxel in Recurrent Metastatic Breast Cancer, A Study of Intravital Microscopy (IVM) in Human Solid Tumors, A Study to Evaluate ATRC-101 in Adults with Advanced Solid Malignancies, MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment, A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer, A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumors, Aggressive Malignancy PDX (Avatar) and Cryopreservation Program, A Study of Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma, A Study of Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors, Establishment of a Biorepository of Baseline and Follow-up Saliva Samples Collected from Newly Diagnosed, Treatment-naïve Cancer Patients, A Study to Evaluate Precision Pharmacogenomics in Cancer Patients, A Study to Evaluate the Effectiveness and Safety of Rivaroxaban as Prophylaxis Treatment for Venous Thromboembolism (VTE) in Ambulatory Cancer Patients, Temsirolimus and Bevacizumab in Treating Patients with Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer, A Study of Sonidegib and Pembrolizumab in Advanced Solid Tumors, A Study of Epacadostat in Combination With Pembrolizumab and Chemotherapy in Subjects With Advanced or Metastatic Solid Tumors (ECHO-207/KEYNOTE-723), hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse, A Study of Mogamulizumab Combined with Nivolumab in Patients who have Locally Advanced or Metastatic Solid Tumors, Mayo Clinic Cancer Genomics Service Line Biorepository, A Phase 1/2 Study of CYT-0851, an Oral RAD51 Inhibitor, in B-Cell Malignancies and Advanced Solid Tumors, A Study to Evaluate the Challenges, Behavioral Patterns, and Preferences of Minority Patient Participation in Clinical Trials, A Study to Evaluate Exercise for Cancer Patients at Risk of Falling, The Circulating Cell-free Genome Atlas Study, Advertising and sponsorship opportunities. , not prevent, pancreatic cancer treatments developed in the proposed phase I study participant tumor markers and pharmacokinetics PK! 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