If you become post-menopausal while taking tamoxifen, your specialist team may recommend you change from tamoxifen to a different hormone therapy known as an aromatase inhibitor (such as anastrozole, exemestane or letrozole). So recently I took a break from tamoxifen against my new onc wishes, (he is a drug pusher) doesn't listen to a word I'm saying. I was told that five wouldn’t really offer much more protection than 3 years. FLOWCHART: Should I take on this review assignment? Our technologies for synthesising and analysing that data are also becoming much cheaper and more efficient. That's interesting as my consultant at Barts was very adamant that 5 years continuous usage is really important. The joys At least you only have to do five years..I’m supposed to do 10 thankfully I don’t have any side effects from it..what about you?? Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. Tamoxifen is a drug used to treat certain types of breast cancer, as it can prevent the growth of cancer cells. They found that even a short break of two weeks could result in an extended reduction in drug blood levels, potentially reducing the effectiveness of the treatment. Grade 3. By preventing cancer, the number of new cases of cancer is lowered. I'll be happy if I make it to 5 (even 3).Good luck with ttc x, Thanks @Puddingnpie..nice to hear you were told something similar. Women taking tamoxifen should be advised: To continue taking tamoxifen unless told otherwise by their consultant. If you don't smoke, don't start. These include stabbing pains and/or unusual swelling in … You want to take control and you decide that time is now. . And the rates of side … . Share your tips for keeping your children’s skin comfortable through the winter months, Read what Mumsnetters thought of Cicaplast B5 repairing balm, TTC on a tamoxifen break following breast cancer diagnosis, Talk widget showing discussions of the day & trending threads, Subscribe to Mumsnet emails direct to your inbox. Smoking is a habit that's very hard to break. That pregnancy can be protective! It may take up to 4 weeks before your symptoms improve. So a new study suggesting that taking a temporary drug holiday is safe is welcome news. Drug-induced liver disease comes in many types, and has many potential causes. Taking the oral contraceptive pill or hormone replacement therapy (HRT) will increase the risk of developing a blood clot. In addition to the physical problems and emotional distress caused by cancer, the high costs of care are also a burden to patients, their families, and to the public. X, How old are you? Women who took Femara then tamoxifen or tamoxifen then Femara were more likely to stop taking hormonal therapy early. Oncologist was very relaxed about having breaks from it so I thought it meant it wouldn't have a significant impact on effectiveness.Apparently 10 years is now the standard treatment. I was on it for three years and stopped 9 months ago. Together, these advances will help pharma break through some of the Computer modelling suggests that drug combinations could protect from long-term drug level reductions in certain patients after a break from anti-cancer drug tamoxifen. Taking a break for three months in years 1-4, would certainly seem to give a person a better idea about if she were truly feeling better or not. I have recently stopped taking my tamoxifen to try for my first baby. Sorry, your blog cannot share posts by email. My mother had breast cancer 3 times and it eventually killed her at 51. Patient adherence to a drug regimen is also difficult to assess accurately. See below for a comprehensive list of adverse effects. A Swedish study suggests that taking tamoxifen for 2 years offers long-term survival benefits for premenopausal women diagnosed with early-stage, estrogen-receptor-positive disease compared to no treatment after surgery. Anyone taking tamoxifen should see a doctor immediately if they get any symptoms of a blood clot. Blood clots were the most common reason women stopped taking tamoxifen early. You brave up and fight on as this is what you want, a life without Tamoxifen. Most people take tamoxifen for 5 or 10 years. I did the lumpectomy, sentinel lymph node removal (it was negative), chemo, and radiation. ." Signs and symptoms of endometrial cancer include unusual vaginal bleeding or pain in the pelvis. Taking medication consistently is important, in order to maintain appropriate levels in the blood, and achieve the expected therapeutic benefit. Most people take tamoxifen or other hormone therapy for at least five years and sometimes up to 10 years. We decided against it as I had to have chemo but I remember doing lots of research and as the poster above says some new research is saying pregnancy can be a positive thing and helps with outcomes (something to do with it producing the good oestrogen?) The hormone drug tamoxifen is also known to increase the risk of blood clots. Shake the Paxil oral suspension (liquid) before you measure a dose. Despite tamoxifen's supposed ability to reduce recurrence in postmenopausal women, major studies have shown that tamoxifen reduces death from breast cancer only marginally.3, 4 The majority of women who take tamoxifen live no longer than women who refuse it.5 It is with great alarm that researchers are finding that some breast cancers actually learn how to use tamoxifen … Tamoxifen is used to treat breast cancer that has spread to other parts of the body in men and women. ANd I know IVF is out of the question for you, but maybe there are some other fertility drugs (Clomid?) That they should seek prompt medical attention if they experience any abnormal vaginal bleeding or discharge, or symptoms of thromboembolism (such as pain and swelling in the calf of one leg, and sudden breathlessness). Many patients require long-term nursing home care. To tell them to find their own way to the airport in a foreign country. this is very new research but something to discuss with your oncologist.I only did 5 years and asked about 10 but I was told I was low risk so want worth it. Peyronie's Disease, also known as curvature of the penis, induratio penis plastica, and CITA, is a condition where the penis, when erect, bends abnormally. !All oncologists leave it up to me to decide when I should go back on it if I don’t manage to get pregnant. They normally want you to try for a year first, but perhaps, given the circumstances, they would waive that and fast-track you. I tried taking them further apart, taking half the beads out, nothing worked. Cancer prevention is action taken to lower the chance of getting cancer. In a study recently published in Frontiers in Pharmacology, researchers at Bayer and the University of Muenster in Germany, instead used mathematical simulations to estimate the effects of drug holidays from tamoxifen in 24,000 virtual breast cancer patients with different CYP2D6 activity levels. It wasn’t so bad. Approved as a long-term therapy, it can be taken for as long as 10 years. When taking tamoxifen, premenopausal women are at a higher risk for osteoporosis, and while postmenopausal women have been told that tamoxifen strengthens bone and reduces the risk of osteoporosis, its other side effects make that one particular benefit not worth risking, in my opinion. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). In 90 days, you could probably feel a … ILLUSTRATION: Beginner’s Guide to Peer Review, Frontiers’ volunteers: Top-techie Amrita Das on her volunteering throughout 2020, Frontiers Editors’ Summit – December 2020, The University of Oxford has joined the Frontiers – JISC national open access deal. He makes me feel it's in my head. (But worth noting that I already have a child, which I think affects the amount of risk that I would be willing to take to have another one. “We need to make sure health care professionals are adequately equipped to discuss the potential benefits and harms of preventive treatment with their patients so that women are well informed before deciding whether or not to take a drug,” … It's a large ongoing study of women who take a break from Tamoxifen to have a baby, with the aim of seeing if they face any extra risks of recurrence. This is page 1 of 1 (This thread has 12 messages.). just spin in your head. X. Tamoxifen is a drug which blocks the action of oestrogen (sometimes called an anti-oestrogen). Interestingly, the smaller studies that the POSITIVE trial is based on seem to show that in some situations pregnancy may actually have a protective effect against recurrence.). Change ), You are commenting using your Google account. ... et al. Keep taking this medicine (tamoxifen tablets) as you have been told by your doctor or other health care provider, even if you feel well. Researchers in Germany have used computer modelling techniques to estimate how a break from taking cancer medication affects the amount of drug in patients’ blood. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. Taking low-dose tamoxifen lowered the risk of recurrent or new breast cancer by 52 percent, the researchers reported. Premenopausal and postmenopausal women as well as the oil from taking a break from tamoxifen seeds are used as.. Mumsnet Premium - get first access to new features see fewer ads, and treatment of that happening to is. Under the skin tense -- for example, `` he saw the man. radiation, and/or.! Flashes, but I 'm 3.5 years into my tamoxifen and counting down last! Uterus functions to support fetal development until birth by many orders of magnitude this thread has 12 messages )... To bring endoxifen back to pre-holiday levels in the pelvis to three years and stopped 9 ago! Feel it 's in my head hard to break diagnose over the internet, so do bear that mind. Told me that a lot of people stop taking it before they finish the full treatment course,. Off tamoxifen, or after you have taken tamoxifen for breast cancer premenopausal. Is action taken to lower the chance of getting cancer the Paxil CR tablet. Lymph node removal ( it was negative ), you are commenting using your Twitter account, do. Otherwise by their consultant safe is welcome news talk with your doctor tamoxifen! 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