Prempro is given to postmenopausal women who have not had hysterectomies to: reduce hot flashes; treat vaginal dryness, itching, and burning; and, help reduce chances of getting osteoporosis (thin weak bones). And while youre at it, also take 400 micrograms of folic acid daily three months before you plan to get pregnant. It's also nicknamed "the morning-after pill for HIV." It is an antiviral regimen, just like PrEP, except that is has to be started within 3 days of the exposure and lasts one month. I began taking Prempro about 20 years ago and decided to quit and just suffer from the heat about a year and a half ago. . But using progesterone this way is counter to the design of the body because progesterone is naturally higher in the morning. I feel great on this drug and have had no side effects. I highly recommend this product, but the cost is way too high. I am 56 years old and have been on prempro for 10 years. I've read that flax an help quell our symptoms. You could also end up with an upset stomach. You may opt-out of email communications at any time by clicking on If you are using this medicine without a prescription, follow the instructions on the medicine label. I need some help on what to do but I don't know who to talk to. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Anyone try it or have a im a active, healthy 58 yr old woman. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals. I'm sleeping at night. If you miss a dose of this medicine, take it as soon as possible. For more than a year, I tried black kohosh,soy isoflavones, evening primrose, sex essentials, hot plants and wild yam cream to no avail. Within two weeks, I felt so much better. What 11 year old wants sex? My doctor put me on Prempro. No problems at all. My Doctor told me it could take up to 4 weeks to see results. My psychiatrist suggested this and I was able to function again in all aspects of life. My doctor said she believes it would kick my weight in gear and I should start losing, a little worried now after reading some comments however I have noticed a big change in my want to eat.. this is really good!!! Estrogen should not be used to prevent heart disease, stroke, or dementia. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email: questions@fpin.org. A: Prempro is a medicine that contains two kinds of hormones: estrogens and a progestin. The only objection I have is the urine from horses. All rights reserved. The only thing left is this caused my cancer and a very very bad surgery please ladies dont take this medication . My hair stopped falling out. I very reluctantly asked my doctor for hormone replacement. Good Luck to all. Ask your doctor if you have any questions. D and calcium. Prempro gave me my life back. Empty the contents of a 2.5 milligrams (mg) packet of powder into a container containing 5 mL of water. If you decide to stop because you're at low risk of infection, one of the great things about PrEP is that you can always start again, as long as you get tested for HIV beforehand. The only symptoms I have had are tenderness in the breast area. So started low dose Prempro. Do not crush, break, or chew the capsule or the tablet. I began taking Prempro about 20 years ago and decided to quit and just suffer from the heat about a year and a half ago. Hello The dose is usually 5 to 20 mg once a day before a meal. I can't afford it at that price. I cannot believe that it took me this many years to do this. Changes clothes or I'd start freezing, even in mid summer. a migraine headache. The proposed recommendations, recently released by the task force, concluded that pre-exposure prophylaxis (PrEP), a daily pill that helps prevent contracting HIV, can be little-used for anyone . Take Prempro exactly as prescribed by your doctor. A 2011 prospective parallel study of 152 adults newly diagnosed with hypothyroidism secondary to Hashimoto thyroiditis compared the effects of administering levothyroxine in the morning (30 minutes before breakfast) vs. evening (at least two hours after dinner).4 Levothyroxine was initiated at a dosage of 1.6 mcg per kg per day and administered with the closest tablet strength (75, 100, or 125 mcg); the dosage was increased by 25 mcg at six weeks if euthyroidism was not achieved. Advertising on our site helps support our mission. The best time to take a multivitamin is with food so any fat can help with absorption. ", "I was prescribed Prempro 6 years ago at age 53.5 and it proved to be very beneficial. Empty the contents of a 10 mg packet of powder into a container containing 15 mL of water. Prempro should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. After a full three months is when things went downhill: I had breast pain/swelling, fatigue, joint pain, and noticed that I had put 5 lbs on around my midsection (despite working out 6 days a week and not changing my diet). Sync your supplements with your schedule for maximum benefits. Hot flashes were about to finish me off. And while you're at it, also take 400 micrograms of folic acid daily three months before you plan to get pregnant. Take 2 PrEP pills between 2-24 hours before sex. I waited almost a year and my menstrual cycle never came back but I started having severe hot flashes several times a day and still having seizures and panic attacks. Check with your physician if you have any of the following: Select a condition to view a list of medication options. After reading these reviews, this med scares me a little. Other Dr's have said don't do that. After a few weeks I started experiencing hot flashes and insomnia. Talk with your healthcare provider regularly about whether you should continue taking PREMPRO or PREMPHASE; See your healthcare provider right away if you get vaginal bleeding while taking PREMPRO or PREMPHASE; Have a pelvic exam, breast exam and mammogram (breast X-ray) every year unless your healthcare provider tells you something else . Estrogen lowers the hormone needed to produce breast milk and can slow breast milk production. To make sure Prempro is safe for you, tell your doctor if you have ever had: liver problems, or jaundice caused by pregnancy or taking hormones; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); Using Prempro may increase your risk of cancer of the breast, uterus, or ovaries. I have energy, memory fog has lifted and still getting better each day. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www.cebm.net). Doctor said he won't prescribe me an alternative HRT.Read More Read Less. After that subsided it's been great. HRT works for me and I'll probably have to take it until I die. The applesauce should not be hot and should be soft enough to be swallowed without chewing. I'm 57 now and I plan on taking this low dose for the rest of my life. Have been taking Prempro for approx. Im so happy prempro is working. a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina. It's unclear whether these risks apply to a younger woman who's on Prempro due to premature ovarian failure or POF. But if youre not eating enough calcium-rich foods or youre postmenopausal, Dr. Perez-Gallardo says youll need to take calcium the right way to decrease bone loss and osteoporosis. a clot in the small veins that carry blood to or from the retina of the eye. The dose is usually taken together with clarithromycin or clarithromycin plus amoxicillin. Super frustrating because it started out so promising. Children 1 year of age and olderDose is based on body weight and must be determined by your doctor. Create an account with us and you'll be able to: Fill in your email below to request a new password. Some doctors still try to move you to a vegetable supplement which does not work!! : No, it will not. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Everyone you can Google Canadian pharmacies and get it CHEAPER! That was 8 years ago. Drug companies are trying to protect themselves & will scare you to death to do that, I was traveling and lost a packet. Downside it is expensive. Feel tired all day and my twice weekly 1/2 marathon runs have become gruelling. All Rights Reserved. The frequency of the flashing has decreased and when it tries to come back it isn't as intense. Your provider can check your levels to see if and where you are deficient, then get you what you need., Cleveland Clinic is a non-profit academic medical center. The dose is usually 2.5 to 10 mg once a day before a meal. Also, not as hungry as normal. privacy practices. I was put on prempro cause of hot flashes and night sweats and vaginal dryness. And sex.forget it! Standard dosage: 0.625 conjugated estrogen/2.5 mg MPA (daily with Prempro; with Premphase, you take the progestin only 2 weeks out of the month). I have also noted a decrease in my appetite which for awhile there was the same as a teenaged boy! Maddie6. The American Thyroid Association recommends that levothyroxine be consistently taken 60 minutes before breakfast or at bedtime, at least three hours after dinner.5. Severe headaches,nausea, chest pains and severe mood swings. Things to remember when you fill your prescription. I would rather deal with the hot flashes and hair loss than the acid reflux flare ups. And yes, some women are given progesterone at night to help them sleep. I tried using the App GoodRX and the coupon was for $206.00. Thanks for the article. Once-daily antihistamines reach their peak 12 hours . The best time to take calcium depends on the kind you take, explains Dr. Perez-Gallardo. There is a problem with Prempro is a daily medication that should result in relatively stable levels regardless of timing. You need at least 2 hours so that the PrEP can start working its way into your system to create a barrier. Advertising on our site helps support our mission. The daily high and low values both signals the need for more hormone production, and help decrease the risk of developing hormone resistance a situation where the cells of the body become resistant to hormone messages because the hormones do not drop as they should. To help relieve this pain, antacids may be taken with omeprazole, unless your doctor tells you otherwise. So, youll want to be careful and not overdo it with calcium. increased risk of blood clotting. 2005 - 2023 WebMD LLC. Within two weeks, I felt so much bette. information and will only use or disclose that information as set forth in our notice of I went to my OBgyn and had her remove my IUD because I thought it was all hormone related. I asked to please stay on Prempro as I believe my quality of life is far more important than the slight risks associated with extended use. I am going to start half the dose to see how my body reacts. I liked the vitamins but I really love what Prempro gave me. This is not a pleasant drug to go off as all the synptons u went on it for come back.i have been using it for over 20 years. I am 65 yrs. The Best IOL for 2022 RXSight Light Adjusted Lens, Will refractive surgery such as LASIK keep me out of glasses all my life. let me know if you find anything that works for you so I can talk to my doctor about it .Thanks for your time.. cheetarun. Bedtime administration resulted in significantly higher mean TSH levels compared with before-breakfast (fasting) administration (2.19 mIU per L vs. 1.06 mIU per L; P < .001), but significantly lower mean TSH levels compared with breakfast (nonfasting) administration (2.19 mIU per L vs. 2.93 mIU per L; P = .026). If some of these hormones are too high in the evening, they interfere with the release of night-time hormones. It's been eight weeks since I've stopped. Have not had a period in 5 years and after starting on this, had discharge and slight spotting, always needing a pantie liner. Im afraid Im going to jinx it by saying this, I have been sleeping like a brick. Mood swings are still there as well so Im hoping after 1 week I see a big change.. wish me luck", "I started Prempro in 2009, still taking it 9 years later at age 62. My psychiatrist suggested this and I was able to function again in all aspects of life. I started taking my pills at night because they make you a bit relaxed or tired but overall, I love it!! Theres was a 330 million dollar lawsuit against prempro. Had a partial colon resection, especially if doctors removed part of your ileum (where vitamin B12 is absorbed in your intestine). Premarin (conjugated estrogens) can be taken in the morning or at night as long as it is taken at the same time every day. I have been on Prempro (lowest dose available) for 10 years and love it!! Add 5 mL to a catheter tipped syringe and then add the contents of a 2.5 mg packet (or 15 mL of water for the 10 mg packet). Children 1 month to younger than 1 year of ageDose is based on body weight and must be determined by your doctor. Within 4 days, hot flashes subsided, within 1 week, they were gone! I was having 4 per hour, each lasting 4-6 minutes, 24/7. I'm 72 and STILL suffering from hot flashes. LINDA CONTILLO GARUFI, MD, MEd, KATARZYNA JABBOUR, PharmD, BCPS, SUSAN E. HANSEN, MA, BRIAN STELLO, MD, AND KRISTINE A. PETRE, MLS, AHIP, CCM, Lehigh Valley Health Network, Allentown, Pennsylvania. Oral estradiol has shorter half life and has to be taken every 12 hours All My Best, Speaking of Women's Health Nurse March 8, 2019 at 9:43am Tweet Stay Connected. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke. Copyright 1996-2023 Cerner Multum, Inc. Children younger than 1 month of ageUse and dose must be determined by your doctor. I hope this helps someone. I believe they could make a synthetic with the same properties of horse urine but apparently they don't care or don't want to spend the money. (Strength of Recommendation: C, disease-oriented outcome.) and my doc. Tonight will be my 4th dose and I honestly cannot wait to see how I feel after a week. No hot flashes and sleeping much better at night, Now that I am at 3 months of medication, I am more tired and now have weight gain! Patients received each regimen for 60 days, and TSH levels were measured at the end of each phase. Changes to meal timing, medication compliance, or levothyroxine timing occurred at a rate of 1.2%. An email will be sent to the address below containing a link to verify your email address. So The million dollar question is will the symptoms start where they left off and run for five years? I am so happy I made this decision because my life is now amazing. At 12 weeks, there was no significant difference in mean TSH levels between the morning and evening dosing groups (5.13 mIU per L vs. 3.27 mIU per L; P = .31). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. For oral dosage form (powder for suspension): To prevent upper gastrointestinal tract bleeding in seriously ill patients: AdultsThe first day: 40 milligrams (mg) for the first dose, then after 6 to 8 hours, a second 40 mg dose. This information is not intended to endorse any particular medication. side effects. Good to hear from you again, Lisa. These side-effects became unbearable so I had my doctor switch me to a bioidentical HRT. Drug companies are trying to protect themselves & will scare you to death to do that, I was traveling and lost a packet. I've been taking the lowest dosage of Prempro for approximately six months and it has worked well to say the least. However, another study found that evening administration was less effective than administration at least 60 minutes before breakfast. So will eating food cooked with oil. Does taking levothyroxine in the evening vs. morning reduce its effectiveness for reducing thyroid-stimulating hormone (TSH) levels? Saving the best for last, it restores the vagina from the ravaging effects of menopausal changes such as dryness and pain during sex. I started out on the highest dose and 3 or 4 yrs ago switched to the lowest dosage. After the first day: 40 mg once a day for up to 14 days. So much for the doctor listening to the patient. The daily cycle of hormone production is described as a circadian rhythm a 24 hour rhythm. It was the worst two years of my life. I haven't had a period in over 4yrs . Thank you for reading my story. WebMD does not provide medical advice, diagnosis or treatment. LOVING IT. My sex drive is non-existent but I have a new, very strong, cuddle drive. But using progesterone this way is counter to the design of the body because progesterone is naturally higher in the morning. Take once-a-day antihistamines in the evening. Ive been taking this medication for about a year to combat intense hot flashes. So now Im going to go to another different doctor to see what else can be done to prevent my misery. Im 61 y.o. Take omeprazole powder for oral suspension on an empty stomach at least 1 hour before a meal. If any medicine remains after drinking, add more water, stir, and drink immediately. It may take several days before this medicine begins to relieve stomach pain. Lets say you are biologically programmed to have 6 years ofmemopause symptoms (i've already had 4 years) but you started replacement tharapy in year 1, and say that you've been on replacment therapy for five years. Talk with your doctor about this risk. Had a stroke or heart attack Currently have or have had blood clots Currently have or have had liver problems Have been diagnosed with a bleeding disorder Are allergic to PREMPRO or PREMPHASE or any of their ingredients . Take omeprazole capsules or delayed-release capsules before a meal, preferably in the morning. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. I plan to stop medication. Ask your healthcare professional how you should dispose of any medicine you do not use. To use the delayed-release oral suspension: If you are using the delayed-release oral suspension with a nasogastric or gastric tube: The dose of this medicine will be different for different patients. And I to get benign cysts on my breast . I have begun to have some hot flashes and night sweats and headaches. I do experience increased appetite, occasional constipation; gained 10 lbs. ChildrenUse and dose must be determined by your doctor. vaginal inflammation due to loss of hormone stimulation, tumor that is dependent on estrogen for growth, a condition with low thyroid hormone levels, inherited disorder of continuing episodes of swelling, a clot in the small veins that carry blood to or from the retina of the eye, obstruction of a blood vessel by a blood clot, blood clot in a deep vein of the extremities, systemic lupus erythematosus, an autoimmune disease, bedridden patient or one unable to move around freely, a disorder of the blood vessels of the brain, thrombophlebitis, an inflamed vein due to a blood clot, decreased calcification or density of bone. A collection of FPINs Clinical Inquiries published in AFP is available at https://www.aafp.org/afp/fpin. Adults20 milligrams (mg) once a day for 4 to 8 weeks. What a wonderful little pill!!! A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. I was back to the hormone level of an 11 year old. Stir and leave it for 2 to 3 minutes to thicken. The amount of medicine that you take depends on the strength of the medicine. Copyright 2023 American Academy of Family Physicians. Been taking Prempro 0.3/1.5 mg for almost 2 months and the night sweats are gone and sex is much better. Take the medicine at the same time each day. My recovery is still on going but Im healing daily . If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. While they are important throughout pregnancy, the best time to start taking prenatal vitamins is before you're pregnant when you're planning to conceive, says Dr. Perez-Gallardo. For oral dosage forms (capsules, delayed-release capsules or suspension, or tablets): Adults20 milligrams (mg) once a day before a meal. So I decided to go off Prempro. Medically reviewed by Philip Thornton, DipPharm. I don't smoke or drink. ", "I am just starting on PremPro. Copyright Family Physicians Inquiries Network. As 4 the severe side effects go through most drugs u take and u will see the same ones. I had one pregnancy. All rights reserved. I'm so confused and don't know what to do. Cleveland Clinic 1995-2023. Learn more about Premarin . Hope it keeps working. Good luck!". Any advice from anyone I would appreciate it. I was actually able to sleep my full time without waking up!!! I had hot flashes but moderately. Hi, I am a 62 year old woman, and after almost 12 years on Prempro, I decided it was time to stop taking it. A 2015 randomized, double-blind, placebo-controlled, crossover study compared the effects of morning (30 minutes before breakfast) vs. evening (60 minutes before dinner) administration of levothyroxine in 50 adults with hypothyroidism.3 A therapeutic TSH level was required for inclusion.